cenobamate will lessen the level or influence of fentanyl transdermal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Intently. Maximize dose of CYP3A4 substrate, as necessary, when coadministered with cenobamate.avapritinib and fentanyl transdermal both equally maximize sedation. Steer clear of or Use Alte